Evidence for the 4+2 Diabetes Reversal Strategy
The 4+2 Diabetes Reversal Strategy programs are based on the research of Dr. Roy Taylor and his team in Newcastle over the past 20 years. Taylor has shown that Type 2 Diabetes is a disease of energy overload. Energy, from food, stored as fat, overwhelms our body’s healthy storage capabilities. Fat is then stored in places it shouldn’t be - within the cells of the liver, pancreas and muscle initially causing insulin resistance and eventually pancreatic beta cell dysfunction, abnormal blood sugars and diabetes.
From cellular studies, to MRI imaging, all the way to a randomized controlled primary care study, Taylor developed the Twin Cycle Theory to explain the pathogenesis of Type 2 Diabetes and most importantly demonstrated the reversibility and potential for diabetes remission. Getting rid of the fat in the liver and pancreas, restores insulin sensitivity and improves beta cell function. The amount of fat in each organ is relatively small - 400g in the liver and only 5g in the pancreas. However to achieve these reversals most people need to lose significant weight. In the DiRECT study, Taylor and his colleagues showed that 86% of people who lost > 15kg of weight were able to achieve reversal of their diabetes.
Demonstration of diabetes reversal in primary care.
Demonstrated the return of pancreatic insulin response with decrease of pancreatic fat from a 15% weight loss.
Beneficial changes of weight loss persist with weight stability.
Translating aetiological insight into sustainable management of type 2 diabetes